TERT

GENE INFORMATION

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Gene name

TERT (HGNC Symbol)

Synonyms

EST2, hEST2, TCS1, TP2, TRT

Description

Telomerase reverse transcriptase (HGNC Symbol)

Entrez gene summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

p15.33

Chromosome location (bp)

1253262 - 1295184

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164362 (version 75.37)

Entrez gene

7015

UniProt

O14746 (UniProt - Evidence at protein level)

neXtProt

NX_O14746

Antibodypedia

TERT antibodies
 

PROTEIN VIEW

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TERT-001
 
TERT-004
 
TERT-005
 
TERT-006
 
TERT-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TERT-001 ENSP00000309572
ENST00000310581
O14746
Show all »
Show » Show » 1132 127 No 2
TERT-004 ENSP00000425003
ENST00000460137
O14746
Show all »
Show » Show » 795 89 No 2
TERT-005 ENSP00000334346
ENST00000334602
O14746
Show all »
Show » Show » 1069 120 No 2
TERT-006 ENSP00000426042
ENST00000508104
O14746
Show all »
Show » Show » 807 90.2 No 2
TERT-201 ENSP00000296820
ENST00000296820
O14746
Show all »
Show » Show » 807 90.2 No 2