TNFRSF11B

GENE INFORMATION

? »

Gene name

TNFRSF11B (HGNC Symbol)

Synonyms

OCIF, OPG, TR1

Description

Tumor necrosis factor receptor superfamily, member 11b (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]

Chromosome

8

Cytoband

q24.12

Chromosome location (bp)

119935796 - 119964439

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000164761 (version 75.37)

Entrez gene

4982

UniProt

O00300 (UniProt - Evidence at protein level)

neXtProt

NX_O00300

Antibodypedia

TNFRSF11B antibodies
 

PROTEIN VIEW

? »
 
 
 
TNFRSF11B-001
 
TNFRSF11B-002
 
 
 
 
 

PROTEIN INFORMATION

? »

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TNFRSF11B-001 ENSP00000297350
ENST00000297350
O00300
Show all »
Show » Show » 401 46 Yes 0
TNFRSF11B-002 ENSP00000427924
ENST00000517352
E5RFV7
Show all »
Show » Show » 145 16.9 Yes 0