TPP1

GENE INFORMATION

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Gene name

TPP1 (HGNC Symbol)

Synonyms

CLN2

Description

Tripeptidyl peptidase I (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008]

Chromosome

11

Cytoband

p15.4

Chromosome location (bp)

6634000 - 6640692

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000166340 (version 75.37)

Entrez gene

1200

UniProt

O14773 (UniProt - Evidence at protein level)

neXtProt

NX_O14773

Antibodypedia

TPP1 antibodies
 

PROTEIN VIEW

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TPP1-001
 
TPP1-003
 
TPP1-008
 
TPP1-017
 
TPP1-019
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

TPP1-001 ENSP00000299427
ENST00000299427
O14773
Show all »
Show » Show » 563 61.2 Yes 0
TPP1-003 ENSP00000437066
ENST00000533371
O14773
Show all »
Show » Show » 320 34.5 No 0
TPP1-008 ENSP00000435001
ENST00000528657
E9PME9
Show all »
Show » Show » 30 3.3 Yes 0
TPP1-017 ENSP00000434647
ENST00000528571
E9PPA4
Show all »
Show » Show » 39 4.3 Yes 0
TPP1-019 ENSP00000398136
ENST00000436873
E7EV34
Show all »
Show » Show » 177 19.4 Yes 0