PRDX2

GENE INFORMATION

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Gene name

PRDX2 (HGNC Symbol)

Synonyms

MGC4104, NKEFB, PRP, PRX2, PRXII, TDPX1, TSA

Description

Peroxiredoxin 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

Chromosome

19

Cytoband

p13.2

Chromosome location (bp)

12907634 - 12912694

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167815 (version 75.37)

Entrez gene

7001

UniProt

P32119 (UniProt - Evidence at protein level)

neXtProt

NX_P32119

Antibodypedia

PRDX2 antibodies
 

PROTEIN VIEW

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PRDX2-001
 
PRDX2-002
 
PRDX2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PRDX2-001 ENSP00000301522
ENST00000301522
P32119
Show all »
Show » Show » 198 21.9 No 0
PRDX2-002 ENSP00000334063
ENST00000334482
A6NIW5
Show all »
Show » Show » 136 15.1 No 0
PRDX2-201 ENSP00000408905
ENST00000435703
P32119
Show all »
Show » Show » 142 15.8 No 0