GFRA2

GENE INFORMATION

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Gene name

GFRA2 (HGNC Symbol)

Synonyms

GDNFRB, NTNRA, RETL2, TRNR2

Description

GDNF family receptor alpha 2 (HGNC Symbol)

Entrez gene summary

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Chromosome

8

Cytoband

p21.3

Chromosome location (bp)

21547915 - 21669869

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168546 (version 75.37)

Entrez gene

2675

UniProt

O00451 (UniProt - Evidence at transcript level)

neXtProt

NX_O00451

Antibodypedia

GFRA2 antibodies
 

PROTEIN VIEW

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GFRA2-001
 
GFRA2-002
 
GFRA2-003
 
GFRA2-004
 
GFRA2-005
 
GFRA2-006
 
GFRA2-007
 
GFRA2-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GFRA2-001 ENSP00000428518
ENST00000524240
O00451
Show all »
Show » Show » 464 51.5 Yes 0
GFRA2-002 ENSP00000306654
ENST00000306793
J3KNF0
Show all »
Show » 62 7.1 Yes 0
GFRA2-003 ENSP00000429206
ENST00000518077
O00451
Show all »
Show » Show » 331 36.5 Yes 0
GFRA2-004 ENSP00000429979
ENST00000517892
O00451
Show all »
Show » Show » 359 39.6 Yes 0
GFRA2-005 ENSP00000429445
ENST00000517328
O00451
Show all »
Show » Show » 464 51.5 Yes 0
GFRA2-006 ENSP00000428721
ENST00000522071
E5RGR6
Show all »
Show » Show » 265 30.3 Yes 0
GFRA2-007 ENSP00000430622
ENST00000519195
E5RJ44
Show all »
Show » Show » 74 8.6 No 0
GFRA2-201 ENSP00000383592
ENST00000400782
O00451
Show all »
Show » Show » 359 39.6 Yes 0