INPP5D - Gene info - The Human Protein Atlas

INPP5D

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	INPP5D (HGNC Symbol)
Synonyms	hp51CN, SHIP
Description	Inositol polyphosphate-5-phosphatase, 145kDa (HGNC Symbol)
Entrez gene summary	This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Chromosome	2
Cytoband	q37.1
Chromosome location (bp)	233924677 - 234116549
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168918 (version 75.37)
Entrez gene	3635
UniProt	Q92835 (UniProt - Evidence at protein level)
neXtProt	NX_Q92835
Antibodypedia	INPP5D antibodies

PROTEIN VIEW

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INPP5D-001		INPP5D-002		INPP5D-005		INPP5D-006		INPP5D-013		INPP5D-014		INPP5D-015		INPP5D-201		INPP5D-202		INPP5D-203		INPP5D-204

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
INPP5D-001	ENSP00000397421 ENST00000415617	H0Y5Q9 Show all » « Hide H0Y5Q9 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	810	90.6	No	0
INPP5D-002	ENSP00000409018 ENST00000422935	C9JLW2 Show all » « Hide C9JLW2 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding]	221	24.9	No	0
INPP5D-005	ENSP00000415253 ENST00000451407	C9JF09 Show all » « Hide C9JF09 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005515 [protein binding] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	222	25	No	0
INPP5D-006	ENSP00000400151 ENST00000435188	H0Y5Q9 Show all » « Hide H0Y5Q9 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	810	90.6	No	0
INPP5D-013	ENSP00000414835 ENST00000417661	H7C403 Show all » « Hide H7C403 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		130	14	No	0
INPP5D-014	ENSP00000473280 ENST00000491070		Show » « Hide SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		43	4.5	No	0
INPP5D-015	ENSP00000405338 ENST00000445964	H0Y5Q9 Show all » « Hide H0Y5Q9 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	810	90.6	No	0
INPP5D-201	ENSP00000352575 ENST00000359570	Q92835 Show all » « Hide Q92835 [Direct mapping] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 H0Y5Q9 [Target identity:68%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 C9JF09 [Target identity:18%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide Hydrolases SPOCTOPUS predicted membrane proteins Enzymes ENZYME proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0006644 [phospholipid metabolic process] GO:0006661 [phosphatidylinositol biosynthetic process] GO:0006796 [phosphate-containing compound metabolic process] GO:0006915 [apoptotic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008285 [negative regulation of cell proliferation] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016020 [membrane] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030853 [negative regulation of granulocyte differentiation] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0043647 [inositol phosphate metabolic process] GO:0044281 [small molecule metabolic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045621 [positive regulation of lymphocyte differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0050852 [T cell receptor signaling pathway] GO:0050869 [negative regulation of B cell activation] GO:0050900 [leukocyte migration] GO:0051425 [PTB domain binding]	1177	131.9	No	0
INPP5D-202	ENSP00000407916 ENST00000450745	H7C2V3 Show all » « Hide H7C2V3 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 H0Y5Q9 [Target identity:86%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	941	105.3	No	0
INPP5D-203	ENSP00000404610 ENST00000455936	H7C292 Show all » « Hide H7C292 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 H0Y5Q9 [Target identity:86%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	941	105.3	No	0
INPP5D-204	ENSP00000441010 ENST00000538935	F5GXI6 Show all » « Hide F5GXI6 [Target identity:100%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 C9JF09 [Target identity:37%; Query identity:100%] Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1	Show » « Hide SPOCTOPUS predicted membrane proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0004445 [inositol-polyphosphate 5-phosphatase activity] GO:0005515 [protein binding] GO:0008340 [determination of adult lifespan] GO:0009968 [negative regulation of signal transduction] GO:0016064 [immunoglobulin mediated immune response] GO:0017124 [SH3 domain binding] GO:0030889 [negative regulation of B cell proliferation] GO:0034594 [phosphatidylinositol trisphosphate phosphatase activity] GO:0035556 [intracellular signal transduction] GO:0043065 [positive regulation of apoptotic process] GO:0045409 [negative regulation of interleukin-6 biosynthetic process] GO:0045579 [positive regulation of B cell differentiation] GO:0045648 [positive regulation of erythrocyte differentiation] GO:0045656 [negative regulation of monocyte differentiation] GO:0045659 [negative regulation of neutrophil differentiation] GO:0045671 [negative regulation of osteoclast differentiation] GO:0045779 [negative regulation of bone resorption] GO:0046856 [phosphatidylinositol dephosphorylation] GO:0050777 [negative regulation of immune response] GO:0051425 [PTB domain binding]	596	67.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.