GRM5 - Gene info - The Human Protein Atlas

Gene name

GRM5 (HGNC Symbol)

Synonyms

GPRC1E, mGlu5, MGLUR5

Description

Glutamate receptor, metabotropic 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Chromosome

Cytoband

q14.2

Chromosome location (bp)

88237744 - 88799113

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000168959 (version 75.37)

Entrez gene

2915

UniProt

P41594 (UniProt - Evidence at protein level)

Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GRM5-001

ENSP00000305905
ENST00000305432

P41594
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P41594 [Direct mapping]
Metabotropic glutamate receptor 5
A8K5P7 [Target identity:76%; Query identity:100%]
cDNA FLJ75523, highly similar to Homo sapiens glutamate receptor, metabotropic 5 (GRM5), mRNA

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   7TM proteins predicted by MDM
   GPCRHMM predicted membrane proteins
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
G-protein coupled receptors
   GPCRs excl olfactory receptors
Predicted membrane proteins
   Prediction method-based
   # TM segments-based
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)

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GO:0000185 [activation of MAPKKK activity]
GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007206 [phospholipase C-activating G-protein coupled glutamate receptor signaling pathway]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008066 [glutamate receptor activity]
GO:0014069 [postsynaptic density]
GO:0016021 [integral to membrane]
GO:0031687 [A2A adenosine receptor binding]
GO:0040013 [negative regulation of locomotion]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]

1180

128.9

Yes

GRM5-002

ENSP00000376972
ENST00000393294

A8MT20
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A8MT20 [Target identity:100%; Query identity:100%]
Metabotropic glutamate receptor 5

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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)

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GO:0004930 [G-protein coupled receptor activity]
GO:0016021 [integral to membrane]

298

33.6

Yes

GRM5-003

ENSP00000403724
ENST00000449371

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Protein evidence (Kim et al 2014)

10.1

GRM5-004

ENSP00000376975
ENST00000393297

P41594
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P41594 [Direct mapping]
Metabotropic glutamate receptor 5

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942

105.4

Yes

GRM5-005

ENSP00000306138
ENST00000305447

P41594
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P41594 [Direct mapping]
Metabotropic glutamate receptor 5

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1212

132.5

Yes

GRM5-201

ENSP00000402912
ENST00000418177

P41594
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P41594 [Direct mapping]
Metabotropic glutamate receptor 5

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GO:0000185 [activation of MAPKKK activity]
GO:0002029 [desensitization of G-protein coupled receptor protein signaling pathway]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral to plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007206 [phospholipase C-activating G-protein coupled glutamate receptor signaling pathway]
GO:0007216 [G-protein coupled glutamate receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007612 [learning]
GO:0007626 [locomotory behavior]
GO:0008066 [glutamate receptor activity]
GO:0014069 [postsynaptic density]
GO:0016020 [membrane]
GO:0016021 [integral to membrane]
GO:0031687 [A2A adenosine receptor binding]
GO:0040013 [negative regulation of locomotion]
GO:0043005 [neuron projection]
GO:0043197 [dendritic spine]
GO:0043198 [dendritic shaft]
GO:0048169 [regulation of long-term neuronal synaptic plasticity]
GO:0048170 [positive regulation of long-term neuronal synaptic plasticity]
GO:0097449 [astrocyte projection]

1212

132.5

Yes

GRM5-202

ENSP00000405690
ENST00000455756

P41594
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1180

128.9

Yes

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.