GUSB

GENE INFORMATION

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Gene name

GUSB

Synonyms

Description

Glucuronidase, beta (HGNC Symbol)

Entrez gene summary

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.[provided by RefSeq, May 2014]

Chromosome

7

Cytoband

q11.21

Chromosome location (bp)

65425671 - 65447301

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000169919 (version 75.37)

Entrez gene

2990

UniProt

P08236 (UniProt - Evidence at protein level)

neXtProt

NX_P08236

Antibodypedia

GUSB antibodies
 

PROTEIN VIEW

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GUSB-001
 
GUSB-002
 
GUSB-004
 
GUSB-007
 
GUSB-008
 
GUSB-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GUSB-001 ENSP00000302728
ENST00000304895
P08236
Show all »
Show » Show » 651 74.7 Yes 0
GUSB-002 ENSP00000391390
ENST00000421103
E9PCV0
Show all »
Show » Show » 505 58.3 Yes 0
GUSB-004 ENSP00000416793
ENST00000446111
F2Z3L6
Show all »
Show » Show » 144 16.7 Yes 0
GUSB-007 ENSP00000411262
ENST00000447929
F2Z3L6
Show all »
Show » Show » 144 16.7 Yes 0
GUSB-008 ENSP00000411859
ENST00000430730
F8WBK6
Show all »
Show » Show » 134 15.6 Yes 0
GUSB-201 ENSP00000340734
ENST00000345660
P08236
Show all »
Show » Show » 600 69.1 Yes 0