OSCAR

GENE INFORMATION

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Gene name

OSCAR

Synonyms

Description

Osteoclast associated, immunoglobulin-like receptor (HGNC Symbol)

Entrez gene summary

Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex protein family that plays critical roles in the regulation of both innate and adaptive immune responses. The encoded protein may play a role in oxidative stress-mediated atherogenesis as well as monocyte adhesion. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

54597933 - 54606000

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000170909 (version 75.37)

Entrez gene

126014

UniProt

Q8IYS5 (UniProt - Evidence at transcript level)

neXtProt

NX_Q8IYS5

Antibodypedia

OSCAR antibodies
 

PROTEIN VIEW

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OSCAR-001
 
OSCAR-002
 
OSCAR-004
 
OSCAR-005
 
OSCAR-006
 
OSCAR-007
 
OSCAR-008
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

OSCAR-001 ENSP00000365808
ENST00000284648
Q8IYS5
Show all »
Show » Show » 282 30.5 Yes 0
OSCAR-002 ENSP00000352671
ENST00000359649
Q8IYS5
Show all »
Show » Show » 286 30.9 Yes 0
OSCAR-004 ENSP00000351145
ENST00000358375
Q8IYS5
Show all »
Show » Show » 263 28.8 Yes 1
OSCAR-005 ENSP00000348927
ENST00000356532
Q8IYS5
Show all »
Show » Show » 267 29.2 Yes 1
OSCAR-006 ENSP00000304523
ENST00000351806
Q8IYS5
Show all »
Show » Show » 252 27.6 Yes 1
OSCAR-007 ENSP00000375640
ENST00000391760
A8MWV3
Show all »
Show » 161 16.4 Yes 0
OSCAR-008 ENSP00000375641
ENST00000391761
Q8IYS5
Show all »
Show » Show » 271 29.3 Yes 0