VEGFB - Gene info - The Human Protein Atlas

VEGFB

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	VEGFB (HGNC Symbol)
Synonyms	VEGFL, VRF
Description	Vascular endothelial growth factor B (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the PDGF (platelet-derived growth factor)/VEGF (vascular endothelial growth factor) family. The VEGF family members regulate the formation of blood vessels and are involved in endothelial cell physiology. This member is a ligand for VEGFR-1 (vascular endothelial growth factor receptor 1) and NRP-1 (neuropilin-1). Studies in mice showed that this gene was co-expressed with nuclear-encoded mitochondrial genes and the encoded protein specifically controlled endothelial uptake of fatty acids. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Sep 2011]
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	64002010 - 64006259
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000173511 (version 75.37)
Entrez gene	7423
UniProt	P49765 (UniProt - Evidence at protein level)
neXtProt	NX_P49765
Antibodypedia	VEGFB antibodies

PROTEIN VIEW

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VEGFB-001		VEGFB-003		VEGFB-004

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
VEGFB-001	ENSP00000311127 ENST00000309422	P49765 Show all » « Hide P49765 [Direct mapping] Vascular endothelial growth factor B Q7LAP4 [Target identity:100%; Query identity:100%] Vascular endothelial growth factor B; Vascular endothelial growth factor B isoform VEGF-B186	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0006493 [protein O-linked glycosylation] GO:0007507 [heart development] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0030168 [platelet activation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031093 [platelet alpha granule lumen] GO:0035470 [positive regulation of vascular wound healing] GO:0042056 [chemoattractant activity] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051781 [positive regulation of cell division] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060048 [cardiac muscle contraction] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060976 [coronary vasculature development] GO:0070374 [positive regulation of ERK1 and ERK2 cascade]	207	21.6	Yes	0
VEGFB-003	ENSP00000401550 ENST00000426086	P49765 Show all » « Hide P49765 [Direct mapping] Vascular endothelial growth factor B	Show » « Hide Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014)	Show » « Hide GO:0001525 [angiogenesis] GO:0001938 [positive regulation of endothelial cell proliferation] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0006493 [protein O-linked glycosylation] GO:0007596 [blood coagulation] GO:0008083 [growth factor activity] GO:0008201 [heparin binding] GO:0010629 [negative regulation of gene expression] GO:0016020 [membrane] GO:0030168 [platelet activation] GO:0030949 [positive regulation of vascular endothelial growth factor receptor signaling pathway] GO:0031093 [platelet alpha granule lumen] GO:0035470 [positive regulation of vascular wound healing] GO:0042056 [chemoattractant activity] GO:0042493 [response to drug] GO:0042803 [protein homodimerization activity] GO:0043066 [negative regulation of apoptotic process] GO:0043183 [vascular endothelial growth factor receptor 1 binding] GO:0043524 [negative regulation of neuron apoptotic process] GO:0046982 [protein heterodimerization activity] GO:0048010 [vascular endothelial growth factor receptor signaling pathway] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050918 [positive chemotaxis] GO:0050930 [induction of positive chemotaxis] GO:0051781 [positive regulation of cell division] GO:0051897 [positive regulation of protein kinase B signaling cascade] GO:0060048 [cardiac muscle contraction] GO:0060754 [positive regulation of mast cell chemotaxis] GO:0060976 [coronary vasculature development] GO:0070374 [positive regulation of ERK1 and ERK2 cascade]	188	21.3	Yes	0
VEGFB-004	ENSP00000442526 ENST00000541681		Show » « Hide SPOCTOPUS predicted secreted proteins RAS pathway related proteins Protein evidence (Kim et al 2014)		32	2.6	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.