IL17RA

GENE INFORMATION

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Gene name

IL17RA (HGNC Symbol)

Synonyms

CD217, CDw217, hIL-17R, IL-17RA, IL17R

Description

Interleukin 17 receptor A (HGNC Symbol)

Entrez gene summary

Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]

Chromosome

22

Cytoband

q11.1

Chromosome location (bp)

17565844 - 17596583

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000177663 (version 75.37)

Entrez gene

23765

UniProt

Q96F46 (UniProt - Evidence at protein level)

neXtProt

NX_Q96F46

Antibodypedia

IL17RA antibodies
 

PROTEIN VIEW

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IL17RA-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

IL17RA-001 ENSP00000320936
ENST00000319363
Q96F46
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