EDDM3A

GENE INFORMATION

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Gene name

EDDM3A (HGNC Symbol)

Synonyms

FAM12A, HE3-ALPHA

Description

Epididymal protein 3A (HGNC Symbol)

Entrez gene summary

Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]

Chromosome

14

Cytoband

q11.2

Chromosome location (bp)

21214051 - 21216539

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000181562 (version 75.37)

Entrez gene

10876

UniProt

Q14507 (UniProt - Evidence at transcript level)

neXtProt

NX_Q14507

Antibodypedia

EDDM3A antibodies
 

PROTEIN VIEW

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EDDM3A-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EDDM3A-001 ENSP00000315098
ENST00000326842
Q14507
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