SEPT5

GENE INFORMATION

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Gene name

SEPT5 (HGNC Symbol)

Synonyms

H5, HCDCREL-1, PNUTL1

Description

Septin 5 (HGNC Symbol)

Entrez gene summary

This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19701987 - 19712295

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000184702 (version 75.37)

Entrez gene

5413

UniProt

Q99719 (UniProt - Evidence at protein level)

neXtProt

NX_Q99719

Antibodypedia

SEPT5 antibodies
 

PROTEIN VIEW

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SEPT5-001
 
SEPT5-002
 
SEPT5-003
 
SEPT5-004
 
SEPT5-006
 
SEPT5-008
 
SEPT5-009
 
SEPT5-010
 
SEPT5-014
 
SEPT5-015
 
SEPT5-016
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SEPT5-001 ENSP00000391311
ENST00000455784
Q99719
Show all »
Show » Show » 369 42.8 No 0
SEPT5-002 ENSP00000394541
ENST00000438754
Q99719
Show all »
Show » Show » 346 39.3 No 0
SEPT5-003 ENSP00000391731
ENST00000455843
G3XAH0
Show all »
Show » Show » 378 43.8 No 0
SEPT5-004 ENSP00000372515
ENST00000383045
G3XAH0
Show all »
Show » Show » 378 43.8 No 0
SEPT5-006 ENSP00000399685
ENST00000431044
B4DJ62
Show all »
Show » Show » 322 37.4 No 0
SEPT5-008 ENSP00000408678
ENST00000412544
C9JM82
Show all »
Show » Show » 301 34.7 No 0
SEPT5-009 ENSP00000378541
ENST00000395109
F8W9E5
Show all »
Show » Show » 180 20.6 No 0
SEPT5-010 ENSP00000414488
ENST00000431124
E7EPG2
Show all »
Show » Show » 304 33.8 No 0
SEPT5-014 ENSP00000384535
ENST00000406395
E7EX32
Show all »
Show » Show » 337 38.3 No 0
SEPT5-015 ENSP00000385356
ENST00000406172
E7EQM7
Show all »
Show » Show » 248 28.6 No 0
SEPT5-016 ENSP00000404673
ENST00000413258
Show » Show » 106 12.5 No 0