GNB1L

GENE INFORMATION

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Gene name

GNB1L (HGNC Symbol)

Synonyms

GY2, WDR14

Description

Guanine nucleotide binding protein (G protein), beta polypeptide 1-like (HGNC Symbol)

Entrez gene summary

This gene encodes a G-protein beta-subunit-like polypeptide which is a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 6 WD repeats and is highly expressed in the heart. The gene maps to the region on chromosome 22q11, which is deleted in DiGeorge syndrome, trisomic in derivative 22 syndrome and tetrasomic in cat-eye syndrome. Therefore, this gene may contribute to the etiology of those disorders. Transcripts from this gene share exons with some transcripts from the C22orf29 gene. [provided by RefSeq, Jul 2008]

Chromosome

22

Cytoband

q11.21

Chromosome location (bp)

19770747 - 19842462

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000185838 (version 75.37)

Entrez gene

54584

UniProt

Q9BYB4 (UniProt - Evidence at protein level)

neXtProt

NX_Q9BYB4

Antibodypedia

GNB1L antibodies
 

PROTEIN VIEW

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GNB1L-001
 
GNB1L-003
 
GNB1L-004
 
GNB1L-005
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GNB1L-001 ENSP00000331313
ENST00000329517
Q9BYB4
Show all »
Show » Show » 327 35.6 No 0
GNB1L-003 ENSP00000385154
ENST00000403325
Q9BYB4
Show all »
Show » Show » 327 35.6 No 0
GNB1L-004 ENSP00000389412
ENST00000453108
C9JPQ6
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Show » Show » 94 10 No 0
GNB1L-005 ENSP00000384626
ENST00000405009
Q9BYB4
Show all »
Show » Show » 212 22.9 No 0