CARD9 - Gene info - The Human Protein Atlas

CARD9

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	CARD9
Synonyms
Description	Caspase recruitment domain family, member 9 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the CARD protein family, which is defined by the presence of a characteristic caspase-associated recruitment domain (CARD). CARD is a protein interaction domain known to participate in activation or suppression of CARD containing members of the caspase family, and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with the CARD domain of BCL10, a postive regulator of apoptosis and NF-kappaB activation, and is thought to function as a molecular scaffold for the assembly of a BCL10 signaling complex that activates NF-kappaB. Several alternatively spliced transcript variants have been observed, but their full-length nature is not clearly defined. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.3
Chromosome location (bp)	139256355 - 139268133
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000187796 (version 75.37)
Entrez gene	64170
UniProt	Q9H257 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H257
Antibodypedia	CARD9 antibodies

PROTEIN VIEW

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CARD9-001		CARD9-002		CARD9-004		CARD9-201

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
CARD9-001	ENSP00000360799 ENST00000371734	Q9H257 Show all » « Hide Q9H257 [Direct mapping] Caspase recruitment domain-containing protein 9	Show » « Hide Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0009620 [response to fungus] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0042493 [response to drug] GO:0042534 [regulation of tumor necrosis factor biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0045076 [regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045408 [regulation of interleukin-6 biosynthetic process] GO:0046330 [positive regulation of JNK cascade] GO:0050700 [CARD domain binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0051607 [defense response to virus] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	492	56.7	No	0
CARD9-002	ENSP00000451368 ENST00000489932	Q9H257 Show all » « Hide Q9H257 [Direct mapping] Caspase recruitment domain-containing protein 9	Show » « Hide Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0009620 [response to fungus] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0042493 [response to drug] GO:0042534 [regulation of tumor necrosis factor biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0045076 [regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045408 [regulation of interleukin-6 biosynthetic process] GO:0046330 [positive regulation of JNK cascade] GO:0050700 [CARD domain binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0051607 [defense response to virus] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	366	43	No	0
CARD9-004	ENSP00000360797 ENST00000371732	Q9H257 Show all » « Hide Q9H257 [Direct mapping] Caspase recruitment domain-containing protein 9	Show » « Hide Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0009620 [response to fungus] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0042493 [response to drug] GO:0042534 [regulation of tumor necrosis factor biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0045076 [regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045089 [positive regulation of innate immune response] GO:0045408 [regulation of interleukin-6 biosynthetic process] GO:0046330 [positive regulation of JNK cascade] GO:0050700 [CARD domain binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0051607 [defense response to virus] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	536	62.2	No	0
CARD9-201	ENSP00000323719 ENST00000315908	Q9H257 Show all » « Hide Q9H257 [Direct mapping] Caspase recruitment domain-containing protein 9	Show » « Hide Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005737 [cytoplasm] GO:0009620 [response to fungus] GO:0032494 [response to peptidoglycan] GO:0032495 [response to muramyl dipeptide] GO:0032755 [positive regulation of interleukin-6 production] GO:0032760 [positive regulation of tumor necrosis factor production] GO:0032874 [positive regulation of stress-activated MAPK cascade] GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway] GO:0042493 [response to drug] GO:0042534 [regulation of tumor necrosis factor biosynthetic process] GO:0042803 [protein homodimerization activity] GO:0042981 [regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0045076 [regulation of interleukin-2 biosynthetic process] GO:0045087 [innate immune response] GO:0045408 [regulation of interleukin-6 biosynthetic process] GO:0046330 [positive regulation of JNK cascade] GO:0050700 [CARD domain binding] GO:0050830 [defense response to Gram-positive bacterium] GO:0051607 [defense response to virus] GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]	366	43	No	0

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.