PPIA

GENE INFORMATION

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Gene name

PPIA (HGNC Symbol)

Synonyms

CYPA

Description

Peptidylprolyl isomerase A (cyclophilin A) (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]

Chromosome

7

Cytoband

p13

Chromosome location (bp)

44836279 - 44864163

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000196262 (version 75.37)

Entrez gene

5478

UniProt

P62937 (UniProt - Evidence at protein level)

neXtProt

NX_P62937

Antibodypedia

PPIA antibodies
 

PROTEIN VIEW

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PPIA-001
 
PPIA-002
 
PPIA-003
 
PPIA-006
 
PPIA-007
 
PPIA-009
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PPIA-001 ENSP00000419425
ENST00000468812
P62937
Show all »
Show » Show » 165 18 No 0
PPIA-002 ENSP00000430817
ENST00000355968
Q567Q0
Show all »
Show » Show » 105 11.4 No 0
PPIA-003 ENSP00000427976
ENST00000489459
Q567Q0
Show all »
Show » Show » 105 11.4 No 0
PPIA-006 ENSP00000405975
ENST00000451562
C9J5S7
Show all »
Show » Show » 121 13.2 No 0
PPIA-007 ENSP00000394670
ENST00000415933
F8WE65
Show all »
Show » Show » 120 13 No 0
PPIA-009 ENSP00000429251
ENST00000479021
E5RIZ5
Show all »
Show » Show » 58 6.2 No 0