HLA-DRB5

GENE INFORMATION

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Gene name

HLA-DRB5

Synonyms

Description

Major histocompatibility complex, class II, DR beta 5 (HGNC Symbol)

Entrez gene summary

HLA-DRB5 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB5 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008]

Chromosome

6

Cytoband

p21.32

Chromosome location (bp)

32485120 - 32498064

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000198502 (version 75.37)

Entrez gene

3127

UniProt

Q30154 (UniProt - Evidence at protein level)

neXtProt

NX_Q30154

Antibodypedia

HLA-DRB5 antibodies
 

PROTEIN VIEW

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HLA-DRB5-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

HLA-DRB5-001 ENSP00000364114
ENST00000374975
Q30154
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