SSX4B

GENE INFORMATION

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Gene name

SSX4B (HGNC Symbol)

Synonyms

OTTHUMT00000056510

Description

Synovial sarcoma, X breakpoint 4B (HGNC Symbol)

Entrez gene summary

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. Chromosome Xp11 contains a segmental duplication resulting in two identical copies of synovial sarcoma, X breakpoint 4, SSX4 and SSX4B, in tail-to-tail orientation. This gene, SSX4B, represents the more centromeric copy. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

X

Cytoband

p11.23

Chromosome location (bp)

48261524 - 48271344

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000198946 (version 75.37)

Entrez gene

548313

UniProt

O60224 (UniProt - Evidence at transcript level)

neXtProt

NX_O60224

Antibodypedia

SSX4B antibodies
 

PROTEIN VIEW

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SSX4B-001
 
SSX4B-201
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

SSX4B-001 ENSP00000366081
ENST00000376884
O60224
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Show » Show » 188 21.9 No 0
SSX4B-201 ENSP00000380134
ENST00000396928
A8MYD4
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Show » Show » 153 17.9 No 0