KIR3DL2

GENE INFORMATION

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Gene name

KIR3DL2 (HGNC Symbol)

Synonyms

CD158K, cl-5, nkat4, nkat4a, nkat4b

Description

Killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 (HGNC Symbol)

Entrez gene summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several ""framework"" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the ""framework"" loci that is present on all haplotypes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jun 2011]

Chromosome

19

Cytoband

q13.42

Chromosome location (bp)

55361898 - 55378662

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000240403 (version 75.37)

Entrez gene

3812

UniProt

P43630 (UniProt - Evidence at transcript level)

neXtProt

NX_P43630

Antibodypedia

KIR3DL2 antibodies
 

PROTEIN VIEW

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KIR3DL2-001
 
KIR3DL2-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

KIR3DL2-001 ENSP00000325525
ENST00000326321
P43630
Show all »
Show » Show » 455 50.2 Yes 1
KIR3DL2-002 ENSP00000270442
ENST00000270442
P43630
Show all »
Show » Show » 438 48.5 Yes 1