CFHR1

GENE INFORMATION

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Gene name

CFHR1 (HGNC Symbol)

Synonyms

CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2

Description

Complement factor H-related 1 (HGNC Symbol)

Entrez gene summary

This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]

Chromosome

1

Cytoband

q31.3

Chromosome location (bp)

196788887 - 196801319

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000244414 (version 75.37)

Entrez gene

3078

UniProt

Q03591 (UniProt - Evidence at protein level)

neXtProt

NX_Q03591

Antibodypedia

CFHR1 antibodies
 

PROTEIN VIEW

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CFHR1-001
 
CFHR1-002
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CFHR1-001 ENSP00000314299
ENST00000320493
Q03591
Show all »
Show » Show » 330 37.7 Yes 0
CFHR1-002 ENSP00000356394
ENST00000367424
B1AKG0
Show all »
Show » 271 30.9 Yes 0