PCDHA12

GENE INFORMATION

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Gene name

PCDHA12 (HGNC Symbol)

Synonyms

PCDH-ALPHA12

Description

Protocadherin alpha 12 (HGNC Symbol)

Entrez gene summary

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]

Chromosome

5

Cytoband

q31.3

Chromosome location (bp)

140255058 - 140391929

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000251664 (version 75.37)

Entrez gene

56137

UniProt

Q9UN75 (UniProt - Evidence at transcript level)

neXtProt

NX_Q9UN75

Antibodypedia

PCDHA12 antibodies
 

PROTEIN VIEW

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PCDHA12-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

PCDHA12-001 ENSP00000381628
ENST00000398631
Q9UN75
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