RP11-399J13.3

GENE INFORMATION

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Gene name

RP11-399J13.3

Synonyms

Description

Entrez gene summary

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membrane to recycling endosomes or the trans-Golgi network. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ADP-ribosylation factor-like 2 (ARL2) gene. [provided by RefSeq, Dec 2010]

Chromosome

11

Cytoband

q13.1

Chromosome location (bp)

64781654 - 64808042

Protein evidence

Evidence at transcript level (all genes)

Ensembl

ENSG00000273003 (version 75.37)

Entrez gene

29907

UniProt

neXtProt

Antibodypedia

RP11-399J13.3 antibodies
 

PROTEIN VIEW

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RP11-399J13.3-001
 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

RP11-399J13.3-001 ENSP00000476630
ENST00000301886
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