DEPDC5

GENE INFORMATION

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Gene name

DEPDC5 (HGNC Symbol)

Synonyms

DEP.5, KIAA0645

Description

DEP domain containing 5 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the IML1 family of proteins involved in G-protein signaling pathways. The mechanistic target of rapamycin complex 1 (mTORC1) pathway regulates cell growth by sensing the availability of nutrients. The protein encoded by this gene is a component of the GATOR1 (GAP activity toward Rags) complex which inhibits the amino acid-sensing branch of the mTORC1 pathway. Mutations in this gene are associated with autosomal dominant familial focal epilepsy with variable foci. A single nucleotide polymorphism in an intron of this gene has been associated with an increased risk of hepatocellular carcinoma in individuals with chronic hepatitis C virus infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Chromosome

22

Cytoband

q12.2

Chromosome location (bp)

32149944 - 32303012

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000100150 (version 75.37)

Entrez gene

9681

UniProt

O75140 (UniProt - Evidence at protein level)

neXtProt

NX_O75140

Antibodypedia

DEPDC5 antibodies
 

PROTEIN VIEW

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 « 
 
DEPDC5-001
 
DEPDC5-002
 
DEPDC5-003
 
DEPDC5-004
 
DEPDC5-005
 
DEPDC5-006
 
DEPDC5-007
 
DEPDC5-012
 
DEPDC5-014
 
DEPDC5-201
 
DEPDC5-202
 
DEPDC5-203
 
DEPDC5-204
 
DEPDC5-205
 
DEPDC5-206
 
DEPDC5-207
 
 » 
 
 
 
 

PROTEIN INFORMATION

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Splice variant

Ensembl

UniProt

Protein class

Gene ontology

Length
(aa)

Molecular mass
(kDa)

Signal peptide
(predicted)

Transmembrane regions
(predicted)

DEPDC5-001 ENSP00000383107
ENST00000400248
O75140
Show all »
Show » Show » 1572 177.9 No 0
DEPDC5-002 ENSP00000383101
ENST00000400242
O75140
Show all »
Show » Show » 559 63.7 No 0
DEPDC5-003 ENSP00000402173
ENST00000448753
H7C1T0
Show all »
Show » 659 73.3 No 0
DEPDC5-004 ENSP00000371545
ENST00000382111
O75140
Show all »
Show » Show » 1552 173.4 No 0
DEPDC5-005 ENSP00000410544
ENST00000433147
B4DGG3
Show all »
Show » Show » 979 110.2 No 0
DEPDC5-006 ENSP00000371546
ENST00000382112
O75140
Show all »
Show » Show » 1594 180.4 No 0
DEPDC5-007 ENSP00000412057
ENST00000458532
Show » 60 6.8 No 0
DEPDC5-012 ENSP00000416314
ENST00000437411
C9JGS4
Show all »
Show » 45 5 No 0
DEPDC5-014 ENSP00000405351
ENST00000456178
F8WAX3
Show all »
Show » 26 3 No 0
DEPDC5-201 ENSP00000266091
ENST00000266091
O75140
Show all »
Show » Show » 1581 178.8 No 0
DEPDC5-202 ENSP00000371539
ENST00000382105
C9JIN9
Show all »
Show » 1229 138.3 No 0
DEPDC5-203 ENSP00000383105
ENST00000400246
O75140
Show all »
Show » Show » 1552 173.4 No 0
DEPDC5-204 ENSP00000383108
ENST00000400249
O75140
Show all »
Show » Show » 1572 177.9 No 0
DEPDC5-205 ENSP00000440210
ENST00000535622
O75140
Show all »
Show » Show » 1503 170.5 No 0
DEPDC5-206 ENSP00000441358
ENST00000536766
F5GYZ8
Show all »
Show » 664 75.4 No 0
DEPDC5-207 ENSP00000446286
ENST00000539165
B4DGG3
Show all »
Show » Show » 420 48.3 No 0