MUC1 - Gene info - The Human Protein Atlas

MUC1

TISSUE

SUBCELL

CELL LINE

CANCER

GENE INFORMATION

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Gene name	MUC1 (HGNC Symbol)
Synonyms	CD227, PEM, PUM
Description	Mucin 1, cell surface associated (HGNC Symbol)
Entrez gene summary	This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Chromosome	1
Cytoband	q22
Chromosome location (bp)	155158300 - 155162707
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000185499 (version 75.37)
Entrez gene	4582
UniProt	P15941 (UniProt - Evidence at protein level)
neXtProt	NX_P15941
Antibodypedia	MUC1 antibodies

PROTEIN VIEW

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MUC1-001		MUC1-002		MUC1-003		MUC1-005		MUC1-006		MUC1-007		MUC1-008		MUC1-009		MUC1-013		MUC1-014		MUC1-020		MUC1-201		MUC1-202

PROTEIN INFORMATION

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Splice variant	Ensembl	UniProt	Protein class	Gene ontology	Length (aa)	Molecular mass (kDa)	Signal peptide (predicted)	Transmembrane regions (predicted)
MUC1-001	ENSP00000357380 ENST00000368395	B1AVQ5 Show all » « Hide B1AVQ5 [Target identity:100%; Query identity:100%] Mucin-1 subunit alpha Q7Z545 [Target identity:11%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:5%; Query identity:100%] Mucin Q9UMI8 [Target identity:4%; Query identity:100%] Mucin	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Translocations 1TM proteins predicted by MDM COSMIC Somatic Mutations Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0001666 [response to hypoxia] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007565 [female pregnancy] GO:0009986 [cell surface] GO:0016324 [apical plasma membrane] GO:0030855 [epithelial cell differentiation] GO:0071300 [cellular response to retinoic acid]	475	49.2	Yes	1
MUC1-002	ENSP00000357377 ENST00000368392	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A5YRV3 [Target identity:32%; Query identity:100%] MUC1 isoform T12 Q14877 [Target identity:9%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	264	28.4	Yes	1
MUC1-003	ENSP00000389098 ENST00000438413	B1AVQ7 Show all » « Hide B1AVQ7 [Target identity:100%; Query identity:100%] Mucin-1 subunit alpha A5YRV0 [Target identity:100%; Query identity:96%] MUC1 isoform G-LSP A5YRV2 [Target identity:94%; Query identity:100%] MUC1 isoform T11 Q7Z545 [Target identity:23%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:10%; Query identity:100%] Mucin	Show » « Hide Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Translocations 1TM proteins predicted by MDM COSMIC Somatic Mutations Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes COSMIC somatic mutations in cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)		229	24.4	Yes	1
MUC1-005	ENSP00000357374 ENST00000368389	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A6ZIE6 [Target identity:100%; Query identity:94%] MUC1 isoform S-LSP Q7Z545 [Target identity:31%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:14%; Query identity:100%] Mucin	Show » « Hide THUMBUP predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	168	18.3	Yes	0
MUC1-006	ENSP00000357381 ENST00000368396	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A6ZIE7 [Target identity:100%; Query identity:95%] MUC1 isoform M12 A5YRV3 [Target identity:53%; Query identity:100%] MUC1 isoform T12 Q14877 [Target identity:15%; Query identity:100%] Mucin	Show » « Hide MEMSAT3 predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	159	17.1	Yes	0
MUC1-007	ENSP00000338983 ENST00000337604	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A5YRU5 [Target identity:100%; Query identity:96%] MUC1 isoform Z-LSP Q7Z545 [Target identity:19%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:8%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	273	29.6	Yes	1
MUC1-008	ENSP00000339690 ENST00000343256	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta B6ECB3 [Target identity:100%; Query identity:95%] MUC1 isoform J24 Q7Z543 [Target identity:33%; Query identity:100%] Mucin short variant SV3 Q7Z545 [Target identity:26%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:11%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	203	21.6	Yes	1
MUC1-009	ENSP00000342814 ENST00000342482	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A6ZIE4 [Target identity:100%; Query identity:87%] MUC1 isoform M10 Q7Z549 [Target identity:94%; Query identity:100%] Mucin short variant E1 Q14877 [Target identity:14%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	166	17.3	Yes	1
MUC1-013	ENSP00000357383 ENST00000368398	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A6ZIE0 [Target identity:100%; Query identity:100%] HCG1996357, isoform CRA_g; MUC1 isoform M7 Q7Z543 [Target identity:29%; Query identity:100%] Mucin short variant SV3 Q7Z545 [Target identity:23%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:10%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	230	24.6	Yes	1
MUC1-014	ENSP00000357375 ENST00000368390	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A5YRU8 [Target identity:95%; Query identity:100%] MUC1 isoform T8 Q7Z545 [Target identity:20%; Query identity:100%] Mucin short variant SV1 Q14877 [Target identity:9%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	255	27.6	Yes	1
MUC1-020	ENSP00000357378 ENST00000368393	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta Q7Z545 [Target identity:26%; Query identity:100%] Mucin short variant SV1	Show » « Hide THUMBUP predicted membrane proteins COSMIC Somatic Mutations COSMIC Translocations CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	198	21.7	Yes	0
MUC1-201	ENSP00000343482 ENST00000338684	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A6ZIE2 [Target identity:95%; Query identity:100%] MUC1 isoform M8 Q14877 [Target identity:10%; Query identity:100%] Mucin	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	224	23.7	Yes	1
MUC1-202	ENSP00000388172 ENST00000457295	P15941 Show all » « Hide P15941 [Direct mapping] Mucin-1 Mucin-1 subunit alpha Mucin-1 subunit beta A5YRV3 [Target identity:32%; Query identity:100%] MUC1 isoform T12	Show » « Hide COSMIC Translocations Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins COSMIC Somatic Mutations 1TM proteins predicted by MDM CD markers Predicted membrane proteins Prediction method-based # TM segments-based Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	Show » « Hide GO:0000790 [nuclear chromatin] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0002039 [p53 binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005796 [Golgi lumen] GO:0005887 [integral to plasma membrane] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0009986 [cell surface] GO:0010944 [negative regulation of transcription by competitive promoter binding] GO:0016266 [O-glycan processing] GO:0016324 [apical plasma membrane] GO:0036003 [positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0090240 [positive regulation of histone H4 acetylation] GO:1902166 [negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]	259	28.3	Yes	1

The Human Protein Atlas project is funded by the Knut & Alice Wallenberg foundation.